Medical Research MCS & MCAS

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Anyone trying to tell you MCS isn’t real? Let them read all these papers before making up their mind.

Lists, Articles, etc.

International Scientific Declaration on EHS & MCS, Brussels, 2015. Following the 5th Paris Appeal Congress that took place on May 18, 2015, at the Royal Academy of Medicine, Brussels, Belgium. http://www.avaate.org/IMG/pdf/statement_en_definitif.pdf

James Madison University MCS Research Team http://www.mcsresearch.net

Chemical Injury Information Network http://ciin.org/library.html

Dr Walter Crinnion ND http://www.ncbi.nlm.nih.gov/pubmed?term=crinnion%20wj

Chemical ‘soup’ clouds connection between toxins and poor health, Scientific American 23 November 2012. http://www.scientificamerican.com/article/birnbaum-government-toxicologist-qa/

Maternal Chemical and Drug Intolerances: Potential Risk Factors for Autism and Attention Deficit Hyperactivity Disorder (ADHD) Lynne P. Heilbrun, MPH; Raymond F. Palmer, PhD; Carlos R. Jaen, MD; Melissa D. Svoboda, MD, Claudia S. Miller, MD, and Jimmy Perkins, PhD; Journal of the American Board Family Med. 2015;28(4):461-470. http://www.medscape.com/viewpublication/67

The Methylation Cycle http://drmyhill.co.uk/wiki/CFS_-_The_Methylation_Cycle

Dr Martin L Pall http://health-ei.com/treatments/neural_sensitization.html

The Role of the Brain and Mast Cells in MCS by Gunnar Heuser, MD, PhD, FACP http://www.tldp.com/issue/210/roleoftheb.htm

The Mast Cell Disease Society https://tmsforacure.org/research/

William J. Meggs, MD, PHD may have relevant articles/publications available.

Online Articles by Dr Rea a thoracic and cardiovascular surgeon with a strong passion for the environmental aspects of health and disease and founder and director of the Environmental Health Center (EHC-D) http://planetthrive.com/2011/10/throat-constriction/ http://www.ehcd.com/

TDEX – The Endocrine Disruption Exchange http://endocrinedisruption.org

Canadian Human Rights Commission, The Medical Perspective on Environmental Sensitivities by Margaret E. Sears http://www.chrc-ccdp.gc.ca/sites/default/files/envsensitivity_en.pdf

Invisible Disabilities Association Why Go Fragrance Free? http://invisibledisabilities.org/educate/chemicalsensitivities/whygofragrancefree/

Daily Mail (UK) 2 September 2015 Why air fresheners and scented candles can wreck your health: They could cause cancerous DNA mutations and asthma http://www.dailymail.co.uk/femail/article-3220306/Why-air-fresheners-scented-candles-wreck-health-cause-cancerous-DNA-mutations-asthma.html

National Geographic March 5, 2015 Chemical Exposure Linked to Billions in Health Care Costs http://news.nationalgeographic.com/news/2015/03/150305-chemicals-endocrine-disruptors-diabetes-toxic-environment-ngfood/

Occipital Lobe Meningioma in a Patient with Multiple Chemical Sensitivity
Moorhead JF, et al
American Journal of Industrial Medicine, 37(4):443‐446, April 2000

Chemical Sensitivity and Fatigue Syndromes from Hypoxia/Hypercapnia
Ross PM.
Medical Hypotheses, 54(5):734-738, May 2000

Deep Subcortical (including limbic) Hypermetabolism in Patients with Chemical Intolerance: Human PET Studies
Heuser G, et al
Annals of The New York Academy of Sciences, 933:319‐322, March 2001

Organochlorine Pesticides and Chlorinated Hydrocarbon Solvents in the Blood of Chemically Sensitive
Patients [corrected]. A Statistical Comparison with Therapeutic Medication and Natural Hormones.
Rea WJ, et al
Journal of Environmental Biology, 22(3):163‐169, July 2001

Solomon GM, Weiss PM. Chemical contaminants in breast milk: time trends and regional variability. Environ Health Perspect. 2002;110:A339–A347.[PMC free article]

Genetic Susceptibility to Adverse Effects of Drugs and Environmental Toxicants. The Role of the CYP Family of Enzymes
Ingelman‐Sunberg M.
Mutation Research, 482(1‐2):11‐19, October 2001
Pupil Light Reaction of Multiple Chemical Sensitivity Patients to Extremely Low Concentrations of
Formaldehyde
Miyata M, et al
Neuro‐Ophthalmology Japan, 19(2):155‐161, 2002
Mechanisms of Multiple Chemical Sensitivity
Winder C.
Toxicology Letters, 128 (1‐3):85‐97, March 10 2002

Multiple Chemical Sensitivity – An Elevation of Enzyme Induction Thresholds
Mellish CE.
Journal of Nutritional & Environmental Medicine, 12(4):337‐342, Dec. 2002

Markers of Genetic Susceptibility in Human Environmental Hygiene and Toxicology: The Role of Selected CYP, NAT and GST genes
Their R, et al
International Journal of Hygiene and Environmental Health, 206(3):149‐171, June 2003

A Metabolic Basis for Fibromyalgia and its Related Disroders: The Possible Role of Resistance to Thyroid
Hormone
Garrison RL, et al
Medical Hypotheses, 61(2):182‐189, August 2003
Reproducibility of Immunological Test Used to Asses Multiple Chemical Sensitivity Syndrome
Hoover DR, et al
Clinical and Diagnostic Laboratory Immunology, 10(6):1029‐1036, November 2003
The Plasma Cysteine/Sulphate Ratio: A Possible Clinical Biomarker
Moss M.
Journal of Nutritional & Environmental Medicine, 13(4): 215‐229, December 2003
Identification of Responsible Volatile Chemicals that Induce Hypersensitive Reactions to Multiple Chemical Sensitivity Patients Shinohara N Journal of Exposure Science & Environmental Epidemiology, 14(1):84‐91, Jan. 2004

Effect of Exposure to Volatile Organic Compounds on Plasma Levels of Neuropeptides, Nerve Growth Factor and Histamine in Patients with Self‐Reported Multiple Chemical Sensitivity

Kimata H. International Journal of Hygiene and Environmental Health, 207(2):159‐163, February 2004

Mycotoxins and Antifungal Drug Interactions: Implications in the Treatment of Illnesses Due to Indoor
Chronic Toxigenic Mold Exposures
Anyanwu EC
Scientific World Journal, 4:167‐177, March 12 2004
LongTerm Exposure to Low Levels of Formaldehyde Increases the Number of Tyrosine Hydroxylase‐Immunopositive Periglomerular Cells in Mouse Main Olfactory Bulb

Hayashi H, et al Brain Research, 1007(1‐2):192‐197, May 2004

The Endoplasmic Reticulum in Xenobiotic Toxicity
Cribb AE, et al
Drug Metabolism Review, 37(3):405‐442, 2

Chemical Exposures: Genes and Sensitivity
By Angela Spivey
Environmental Health Perspective, 113(3):A157, March 2005

Exposure of Eyes to Perfume: A Double‐Blind, Placebo‐Controlled Experiment
Elbering J et al
Indoor Air, 16(4): 276‐281, August 2006

Drug Intolerance in Patients with Idiopathic Environmental Intolerance Syndrome
Niedoszytko M, et al
The International Journal of Clinical Practice, 60(10):1327‐1329, October 2006

The Role of the Brain and Mast Cells in MCS
Heuser G.
Townsend Letter, October 2006

Relevance of the Deletion Polymorphisms of the Glutathione S‐transferases GSTT1 and GSTM1 in
Pharmacology and Toxicology.
Bolt HM,
Current Drug Metabolism, 7(6):613‐628, Aug 2006
Increased Release of Histamine in Patients with Respiratory Symptoms Related to Perfume.
Elbering J, et al
Experimental Allergy, 37(11):1676‐1680, 2007

Immune Effects of Respiratory Exposure to Fragrance Chemicals
Ezendam J et al
RIVM Reports,  2007

A Cross‐Sectional Study of Self- Reported Chemical Related Sensitivity is Associated with Gene Variants of Drug‐Metabolizing Enzymes

Schnakenberg E, et al.
Environmental Health, 6:6, 2007

Effect of Long‐Term Exposure to Low‐Level Toluene on Airway Inflammatory Response in Mice
Fujimaki H, et al
Toxicology Letters, 168(2):132‐139, January 30 2007

The Effects of Evaporating Essential Oils on Indoor Air Quality
Su HJ, et al
Atmospheric Environment, 41(6):1230‐1236, February 2007

Volatile Organic Compounds Contribute to Airway Hyperresponsiveness
Jang AS, et al
The Korean Journal of Internal Medicine, 22(1):8‐12, March 2007

Odor Processing in Multiple Chemical Sensitivity
Hilbert L, et al
Human Brain Mapping, 28(3):172‐183, March 2007
Quality of Life and Capsaicin Sensitivity in Patients with Airway Symptoms Induced by Chemicals and Scents: A Longitudinal Study
Ternesten‐Hasseus E, et al
Environmental Health Perspective, 115(3):425‐429, March 2007

Gene-Environment Interactions in Environmental Lung Diseases Kleeberger SR, et al Novartis Foundation Symposium, 293:168‐178, 2008

Coagulation Cascade and Fibrinolysis in Patients with Multiple‐Drug Allergy Syndrome
Asero R, et al
Annals of Allergy, Asthma & Immunology, 100(1):44‐48, January 2008

Sequence Variations in Subjects with Self‐Reported Multiple Chemical Sensitivity (sMCS): A Case‐Control Study

Wiesmuller GA, et al. Journal of Toxicology and Environmental Health, 71(11‐12):786‐794, January 2008

The Health Effects of Nonindustrial Indoor Air Pollution
Bernstein J, et al
The Journal of Allergy and Clinical Immunology, 121(3):585‐591, March 2008

Mechanisms of Increased Airway Sensitivity to Occupational Chemicals and Odors
Millqvist E.
Current Opinion in Allergy and Clinical Immunology, 8(2):135‐139, April 2008

Detection of Low‐Level Environmental Chemcal Allergy by a Long‐Term Sensitization Method

Fukuyama T, et al Toxicology Letters, 180(1):1‐8, July 30 2008

Anaesthesia for Patients with Idiopathic Environmental Intolerance and Chronic Fatigue Syndrome
Fisher MM, et al
British Journal of Anaesthesia, 101(4):486‐491, October 2008

Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control Bessac BF, et al Physiology, 23(6):360‐370, December 2008

Cerebral Imaging and Olfactory Disorders: A Review
Plallly J, et al
B‐ENT, 5 Suppl 13:61‐69, 2009

Phenotypes of Individuals Affected by Airborne Chemicals in the General Population
Berg ND, et al
International Archives of Occupational and Environmental Health, 82(4):509‐517, March 2009

Relation of PON1 and CYP1A1 Genetic Polymorphisms to Clinical Findings in a Cross‐Sectional Study of a
Greek Rural Population Professionally Exposed to Pesticides
Tsatsakis AM, et al
Toxicology Letters, 186(1):66‐72, April 10 2009,

Neuroregulation of Human Nasal Mucosa
Baraniuk JN, et al
Annals of The New York Academy of Sciences, 1170:604‐609, July 2009

Glyphosate‐Based Herbicides are Toxic and Endocrine Disrupters in Human Cell Lines
Gasnier C, et al
Toxicology, 262(3):184‐191, August 21 2009

The Chemical Defensive System in the Pathobiology of Idiopathic Environment‐ Associated Diseases
Korkina L, et al
Current Drug Metabolism, 10(8): 914‐931, October 2009

Brain Dysfunction in Multiple Chemical Sensitivity
Orriols R, et al
Journal of Neurological Science, 287(1‐2):72‐8, December 15 2009

How Can We Cure NO/ONOO ‐ Cycle Diseases?
Pall ML
Townsend Letter For Doctors and Patients, 319‐320:75‐86, 2010

Functional Impairment in Chronic Fatigue Syndrome, Fibromyalgia, and Multiple Chemical Sensitivity
Lavergne RM, et al
Canadian Family Physician, 52(2):e57‐e65, February 2010

Xenobiotic, Bile Acid and Cholesterol Transporters: Function and Regulation
Klaassen CD, et al
Pharmacological Reivews, 62(1):1‐96, March 2010
Genetic Susceptibility Factors for Multiple Chemical Sensitivity Revisited
Berg ND, et al.
International Journal of Hygiene and Environmental Health, 213(2): 131‐139, March 2010

Factors Associated with Prospective Development of Environmental Annoyance
Eek F, et al
Journal of Psychosomatic Research, 69(1):9‐15, July 2010

Idiopathic Environmental Intolerance (IEI): From Molecular Epidemiology to Molecular Medicine
De Luca C, et al
Indian Journal of Experimental Biology, 48(7):625‐635, July 2010

Multiple Chemical Sensitivity is a Response to Chemicals Acting as Toxicants via Excessive NMDA Activity
Pall ML
Journal of Psychosomatic Research, 69(3): 327‐328, September 2010

Human PON1, a Biomarker of Risk of Disease and Exposure
Furlong CE, et al
Chemico‐Biological Interactions, 187(1‐3):355‐361, September 6 2010

Biological Definition of Multiple Chemical Sensitivity from Redox State and Cytokine Profiling and not from Polymorphisms of Xenobiotic‐Metabolizing Enzymes

De Luca C, et al
Toxicology and Applied Pharmacology, 248(3): 285‐292, November 1 2010

Debating the Legitimacy of a Contested Environmental Illness: A Case Study of Multiple Chemical
Sensitivities (MCS)
Phillips T.
Sociology of Health & Illness, 32(7):1026‐1040, November 2010

A Novel Methodology to Evaluate Health Impacts Caused by VOC Exposures Using Real‐Time VOC and
Holter Moniters
Mizukoshi A, et al
International Journal of Environmental Research and Public Health, 7(12):4127‐4138,
December 2010

Increased Capsaicin‐Induced Secondary Hyperalgesia in Patients with Multiple Chemical Sensitivity.
Holst H, et al
The Clinical Journal of Pain, 27(2):156‐162, February  2011

NonAllergic Cutaneous Reactions in Airborne Chemical Sensitivity – A Population Based Study
Berg ND, et al
International Journal of Hygiene and Environmental Health, February 14 2011 (Epub ahead of print)

Isolation and lack of Access in Multiple Chemical Sensitivity: A Qualitative Study
Gibson PR, et al
Nursing and Health Sciences, 13(3): 232‐237, 2011

Effect of Exposure to Volatile Organic Compounds (VOCs) on Airway Inflammatory Response in Mice
Wang F, et al
The Journal of Toxicological Sciences, 37(4): 739‐748, 2012

Women with Multiple Chemical Sensitivity Have Increased Harm Avoidance and Reduced 5‐HT1A Receptor
Binding Potential in the Anterior Cingulate and Amygdala
Hillert L, et al
Plos One, 8(1): e54781, 2013

Evaluation of Genetic Polymorphism in Patients with Multiple Chemical Sensitivity
Cui X, et al
Plos One, 8(8): e73708, 2013

Xenobiotic Sensor – and Metabolism‐Related Gene Variants in Environmental Sensitivity Related Illnesses: A
Survey on the Italian Population
Caccamo D, et al
Oxidative Medicine and Cellular Longevity, Epub July 7 2013

Multiple Chemical Sensitivity: On the Scent of Central Sensitization
Tran M.T., et al
International Journal of Hygiene and Environmental Health, 216(2): 202‐210, 2013

Caress S.M., Steinemann A.C.  Prevalence of Fragrance Sensitivity in the American Population.  Journal of Environmental Health 71(7): 46‐50, 2009.

Caress S.M., Steinemann A.C.  National Prevalence of Asthma and Chemical Hypersensitivity: An Examination of Potential Overlap. Journal of Occupational and Environmental Medicine 47(5): 518‐522, 2005.

Caress S.M., Steinemann A.C.  A National Population Study of the Prevalence of Multiple Chemical Sensitivity. Archives of Environmental Health 59(6): 300‐305, 2004.  Abstract

Caress S.M., Steinemann A.C. Prevalence of Multiple Chemical Sensitivities: A Population-Based Study in the Southeastern United States. American Journal of Public Health 94(5): 746‐747, 2004

Caress S.M., Steinemann A.C.  A Review of a Two‐Phase Population Study of Multiple Chemical Sensitivities.
Environmental Health Perspectives 111(12): 1490‐1497, 2003.

Caress S.M., Steinemann A.C., Waddick W. Symptomatology and Etiology of Multiple Chemical Sensitivities in the Southeastern United States. Archives of Environmental Health 57(5): 429‐436, 2002.

Kreutzer R, Neutra R.R, Lashuay N. Prevalence of people reporting sensitivities to chemicals in a population- based survey. American Journal of Epidemiology. 150(1):1‐12, 1999

from Chemical Sensitivity Foundation Research Bibliography
Selected Bibliography of Studies and Articles on Chemical Sensitivity Published in Peer-Reviewed Journals
March 2014 Version http://www.chemicalsensitivityfoundation.org/chemical-sensitivity-research_bibliography.html

  • Abdullah, L., Evans, J.E., Montague, H., Reed, J.M., Moser, A., Crynen, G., Gonzalez, A., Zakirova, Z., Ross, I., Mullan, C., Mullan, M., Ait-Ghezala, G., Crawford, F. “Chronic Elevation of Phosphocholine Containing Lipids in Mice Exposed to Gulf War Agents Pyridostigmine Bromide and Permethrin.” Neurotoxicology and Teratology 40 (November-December, 2013):74-78.
  • Antelman, S.M. “Time-Dependent Sensitization in Animals: A Possible Model of Multiple Chemical Sensitivity in Humans.” Toxicology and Industrial Health 10, nos. 4-5 (July-October 1994):335-42.
  • Arnold Liamosas, P.A., Arrizabalaga Clement, P., Bonet Agusti, M., de la Fuente Brull, X. “Multiple Chemical Sensitivity in Sick-Building Syndrome.” Medicina Clinica (Barcelona) 126, no. 20 (May 27, 2006):774-78.
  • Association of Occupational and Environmental Clinics. “Advancing the Understanding of Multiple Chemical Sensitivity.” Toxicology and Industrial Health 8, no. 4 (1992):1.
  • Ashford, N., Heinzow, B., Lüütjen, K., Marouli, C., Møølhave, L., Möönch, B., Papadopoulos, S., Rest, K., Rosdahl, D., Siskos, P., Velonakis, E., et al. “Chemical Sensitivity in Selected European Countries: An Exploratory Study.” A Report to the European Commission. Ergonomia, 1995.
  • ATSDR (Agency for Toxic Substances and Disease Registry). “Proceedings of the Conference on Low-Level Exposure to Chemicals and Neurobiologic Sensitivity.” Toxicology and Industrial Health 10, nos. 4-5 (1994):25.
  • Baines, C.J., McKeown-Eyssen, G.E., Riley, N., Cole, D.E., Marshall, L., Loescher, B., Jazmaji, V. “Case-Control Study of Multiple Chemical Sensitivity, Comparing Haematology, Biochemistry, Vitamins and Serum Volatile Organic Compound Measures.” Occupational Medicine 54, no. 6 (September 2004):408-18.
  • Bartha, L., Baumzweiger, W., Buscher, D., Callender, M., Dahl, K., Davidoff, A., et al. “Multiple Chemical Sensitivity: A 1999 Consensus.” Archives of Environmental Health 54, no. 3 (1999):147-49.
  • Bascom, R. “Multiple Chemical Sensitivity: A Respiratory Disorder.” Toxicology and Industrial Health 8, no. 4 (1991):221-28.Bascom, R., Meggs, W., Frampton, M., Hudnell, K., Killburn, K., Kobal, G., Medinsky,M., Rea, W. “Neurogenic Inflammation: With Additional Discussion of Central and Perceptual Integration of Nonneurogenic Inflammation.” Environmental Health Perspectives 105, Suppl. 2 (1997):531-37.
  • Bell, I.R. “Clinically Relevant EEG Studies and Psychophysiological Findings: Possible Neural Mechanisms for Multiple Chemical Sensitivity.” Toxicology 111 (1996):101-17.
  • Bell, I.R. “White Paper: Neuropsychiatric Aspects of Sensitivity to Low-Level Chemicals: A Neural Sensitization Model.” Toxicology and Industrial Health 10, nos. 4-5 (July-October 1994):277-312.
  • Bell, I.R., Baldwin, C.M., Schwartz, G.E. “Sensitization Studies in Chemically Intolerant Individuals: Implications for Individual Difference Research.” Annals of the New York Academy of Science 453 (2001):38-47.
  • Bell, I., Baldwin, C., Fernandez, M., Schwartz, G. “Neural Sensitization Model for Multiple Chemical Sensitivity: Overview of Theory and Empirical Evidence.” Toxicology and Industrial Health 15, nos. 3-4 (1999):295-304.
  • Bell, I., Rossi, J., Gilbert, M., Kobal, G., Morrow, L., Newlin, D., Sorg, B., Wood, R. “Testing the Neural Sensitization and Kindling Hypothesis for Illness from Low Levels of Environmental Chemicals.” Environmental Health Perspectives 105, Suppl. 2 (1997):539-47.
  • Berg, N.D., Linneberg, A., Dirksen, A., Elberling, J. “Phenotypes of Individuals Affected by Airborne Chemicals in the General Population.” International Archives of Occupational and Environmental Health (August 28, 2008).
  • Buchwald, D., Garrity, D. “Comparison of Patients with Chronic Fatigue Syndrome, Fibromyalgia, and Multiple Chemical Sensitivities.” Archives of Internal Medicine 154 (1994): 2049-2053.
  • Callender, T.J., Morrow, L., Submaranium, K. “Evaluation of Chronic Neurological Sequelae After Acute Pesticide Poisoning Using Brain SPECT Scans.” Journal of Toxicology and Environmental Health 41 (1994):275-84.
  • Calley, C.S., Kraut, M.A., Spence, J.S., Briggs, R.W., Haley, R.W., Hart, J. Jr. “The Neuroanatomic Correlates of Semantic Memory Deficits in Patients with Gulf War Illnesses: A Pilot Study.” Brain Imaging Behavior 4, nos. 3-4 (December 2010):248-55.
  • Caress, S.M., Steinemann, A.C. “A National Population Study of the Prevalence of Multiple Chemical Sensitivity.” Archives of Environmental Health 59, no. 6 (June 2004): 300-305.
  • Caress, S.M., Steinemann, A.C. “National Prevalence of Asthma and Chemical Hypersensitivity: An Examination of Potential Overlap.” Journal of Occupational and Environmental Medicine 47, no. 5 (May 2005): 518-22.
  • Caress, S.M., Steinemann, A.C. “Prevalence of Fragrance Sensitivity in the American Population.” Journal of Environmental Health 71, no. 7 (2009):46-50.
  • Caress, S.M., Steinemann, A.C. “A Review of a Two-Phase Population Study of Multiple Chemical Sensitivities.” Environmental Health Perspectives 111, no. 12 (2003):1490-1497.
  • Caress, S.M., Steinemann, A.C., Waddick, C. “Symptomatology and Etiology of Multiple Chemical Sensitivities in the Southeastern United States.” Archives of Environmental Health 57, no. 5 (2002):429-36.
  • Cone, J., Sult, T. “Acquired Intolerance to Solvents Following Pesticide/Solvent Exposure in a Building: A New Group of Workers at Risk for Multiple Chemical Sensitivity.” Toxicology and Industrial Health 8, no. 4 (1992):29-39.
  • Costa, L., Li, W., Richter, R., Shih, D., Lusis, A., Furlong, C. “The Role of Paraoxonase (PON1) in the Detoxication of Organophosphates and Its Human Polymorphism.” Chemico-Biological Interactions 119-120 (1999):429-38.
  • Cowan, J., Sinton, C.M., Varley, A.W., Wians, F.H., Haley, R.W., Munford, R.S. “Gene Therapy to Prevent Organophosphate Intoxication.” Toxicology and Applied Pharmacology 173, no. 1 (May 15, 2001):1-6.
  • Cui, X., Lu, X., Hiura, M., Oda, M., Miyazaki, W., et al. “Evaluation of Genetic Polymorphisms in Patients with Multiple Chemical Sensitivity.” PLoS ONE 8, no. 8 (August 13, 2013):e73708.
  • Cullen, M., Pace, P., Redlich, C. “The Experience of the Yale Occupational and Environmental Medicine Clinics with Multiple Chemical Sensitivities, 1986-1991.” Toxicology and Industrial Health 8 (1992):15-19.
  • Cullen, M.R. “The Worker with Multiple Chemical Sensitivities: An Overview.” Occupational Medicine 2 (1987):655-68.
  • Dantoft, T.M., Elberling, J., Brix, S., Szecsi, P.B., Vesterhauge, S., Skovbjerg, S. “An Elevated Pro-Inflammatory Cytokine Profile in Multiple Chemical Sensitivity.” Psychoneuroendocrinology 40 (February 2014):140-50.
  • Davidoff, A., Fogarty, L. “Psychogenic Origins of Multiple Chemical Sensitivity Syndrome: A Critical Review of the Research Literature.” Archives of Environmental Health 49, no. 5 (1994):316-25.
  • Davidoff, A., Keyl, P. “Symptoms and Health Status in Individuals with Multiple Chemical Sensitivities Syndrome from Four Reported Sensitizing Exposures and a General Population Comparison Group.” Archives of Environmental Health 51, no. 3 (1996):201-13.
  • Davidoff, A.L., Meggs, W. “Development of Multiple Chemical Sensitivities in Laborers After Acute Gasoline Fume Exposure in an Underground Tunneling Operation.” Archives of Environmental Health 53, no.3 (1998):183-89.
  • Doty, R., Deems, D., Frye, R., Pelberg, R., Shapiro, A. “Olfactory Sensitivity, Nasal Resistance, and Autonomic Function in Patients with Multiple Chemical Sensitivities.” Archives of Otolaryngology-Head and Neck Surgery 114 (1988):1422-1427.
  • Elberling, J., Dirksen, A., Johansen, J.D., Mosbech, H. “The Capsaicin Cough Reflex in Eczema Patients with Respiratory Symptoms Elicited by Perfume.” Contact Dermatitis 54, no. 3 (March 2006):158-64.
  • Fernandez, M., Bell, I., Schwartz, G. “EEG Sensitization During Chemical Exposure in Women With and Without Chemical Sensitivity of Unknown Etiology.” Toxicology and Industrial Health 15, nos. 3-4 (1999):305-12.
  • Fiedler, N., Kipen, H., Natelson, B., Ottenweller, J. “Chemical Sensitivities and the Gulf War: Department of Veterans Affairs Research Center in Basic and Clinical Science Studies of Environmental Hazards.” Regulatory Toxicology and Pharmacology 24 (1996):S129-S138.
  • Fincher, E.F., Chang, T.S., Harrell, E.H., Kettkecut, M.C., Rea, W.J., Johnson, A.R., Hickey, H.C., Simon, T.R. “Comparison of Single Photon Computed Tomography Findings in Cases of Healthy Adults and Solvent-Exposed Adults.” American Journal of Industrial Medicine 31 (1997):4-14.
  • Fukuyama, T., Ueda, H., Hayashi, K. Tajima, Y., Shuto, Y., Saito, T.R., Harada, T.,Kosaka, T. “Detection of Low-Level Environmental Chemical Allergy by a Long-term Sensitization Method.” Toxicological Letters 180, no. 1 (July 30, 2008):1-8.
  • Galland, L. “Biochemical Abnormalities in Patients with Multiple Chemical Sensitivities.” Occupational Medicine 2, no. 4 (October-December 1987):713-20.
  • Gibson, P. R. “Chemical and Electromagnetic Exposures As Disability Barriers: Environmental Sensitivity.” Disability & Society 24, no. 2 (2009):187-99.
  • Gibson, P.R. “Life Indicators, Illness Characteristics, and Psychosocial Concomitants of Self-Reported Multiple Chemical Sensitivity: A Two-Year Longitudinal Study.” Journal of Nursing Education and Practice 4, no. 3 (2014):204.
  • Gibson, P. R. “Perceived Treatment Efficacy for Conventional and Alternative Therapies Reported by Persons with Multiple Chemical Sensitivity.” Environmental Health Perspectives 111 (2003):1498-1504.
  • Gibson, P. R. “Sickness Related Dysfunction in Persons with Self-Reported Multiple Chemical Sensitivity at Four Levels of Severity.” Journal of Clinical Nursing 18 (2009):72-81.
  • Gibson, P. R. “Work Accommodation for People with Multiple Chemical Sensitivity.” Disability & Society 22, no. 7 (2007):717-32.
  • Gibson, P. R. “Of the World But Not in It: Barriers to Community Access and Education for Persons with Environmental Sensitivities.” Health Care for Women International 31, no. 1: (2010):3-16.
  • Gopinath, K., Gandhi, P., Goyal, A., Jiang, L., Fang, Y., Ouyang, L., Ganji, S., Buhner, D., Ringe, W., Spence, J., Biggs, M., Briggs, R., Haley, R. “FMRI Reveals Abnormal Central Processing of Sensory and Pain Stimuli in Ill Gulf War Veterans.” Neurotoxicology 33. no. 3 (June 2012):261-71.
  • Gordon, B.R. “Approaches to Testing for Food and Chemical Sensitivities.” Otolaryngology Clinics of North America 36, no. 5 (October 2003):917-40.
  • Haley, R., Billecke, S., La Du, B. “Association of Low PON1 Type Q (Type A) Arylesterase Activity with Neurologic Symptom Complexes in Gulf War Veterans.” Toxicology and Applied Pharmacology 157, no. 3 (1999):227-33.
  • Hasegawa, M., Ohtomo, M., Mita, H., Akiyama, K. “Clinical Aspects of Patients with MCS from the Standpoint of Allergy.” Japanese Journal of Allergology 54, no. 5 (May 2005):478-84.
  • Heuser, G. “Diagnostic Markers in Clinical Immunotoxicology and Neurotoxicology.” Editorial. Journal of Occupational Medicine and Toxicology 1, no. 4 (1992):v-x.
  • Heuser, G., Mena, I., Alamous, F. “Neurospect Findings in Patients Exposed to Neurotoxic Chemicals.” Toxicology and Industrial Health 10, nos. 4-5 (1994):461-571.
  • Heuser, G., Mena, I. “Neurospect in Neurotoxic Chemical Exposure. Demonstration of Long-Term Functional Abnormalities.” Toxicology and Industrial Health 14, no. 6 (1998):813-27.
  • Heuser, G., Wu, J.C. “Deep Subcortical (Including Limbic) Hypermetabolism in Patients with Chemical Intolerance: Human PET Studies.” Annals of the New York Academy of Sciences 933 (March 2001):319-22.
  • Hojo, S., Ishikawa, S., Kumano, H., Miyata, M., Sakabe, K. “Clinical Characteristics of Physician-Diagnosed Patients with Multiple Chemical Sensitivity in Japan.” International Journal of Hygiene and Environmental Health 211, nos. 5-6 (October 2008):682-89.
  • Ionescu, G., Merk, M., Bradford, R. “Simple Chemiluminesence Assays for Free Radicals in Venous Blood and Serum Samples: Results in Atopic, Psoriasis, MCS, and Cancer Patients.” Forsch Komplementarmed 6, no. 6 (December 1999):294-300.
  • Inomata, N., Osuna, H., Fujita, H., Ogawa, T. Ikezawa, Z. “Multiple Chemical Sensitivities Following Intolerance to Azo Dye in Sweets in a 5-Year-Old Girl.” Allergology International 55, no. 2 (June 2006): 203-5.
  • Ishibashi, M., Tonori, H., Miki, T., Miyajima, E., Kudo, Y., Tsumoda, M. Sakabe, K., Aizawa, Y. “Classification of Patients Complaining of Sick House Syndrome and/or Multiple Chemical Sensitivity.” Tohoku Journal of Experimental Medicine 211, no. 3 (March 2007):223-33.
  • Jinno, H., Tanaka-Kagawa, T., Obama, T., Miyagawa, M., Yoshikawa, J., Komatsu, K., Tokunaga, H. “Impact of Air Fresheners and Deodorizers on the Indoor Total VolatileOrganic Compounds.” Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku 125 (2007):72-78.
  • Kilburn K. “Effects of Diesel Exhaust on Neurobehavioral and Pulmonary Functions.” Archives of Environmental Health 55, no.1 (January/February 2000).
  • Kimata, H. “Effect of Exposure to Volatile Organic Compounds on Plasma Levels of Neuropeptides, Nerve Growth Factor and Histamine in Patients with Self-Reported Multiple Chemical Sensitivity.” International Journal of Hygiene and Environmental Health 207, no. 2 (February 2004):159-63.
  • Kimata, H. “Exposure to Road Traffic Enhances Allergic Skin Wheal Responses and Increases Plasma Neuropeptides and Neurotrophins in Patients with Atopic Eczema/Dermatitis Syndrome.” International Journal of Hygiene and Environmental Health 207, no 1. (January 2004):45-49.
  • Kipen, H.M., Hallman, W., Kang, H., Fiedler, N., Natelson, B.H. “Prevalence of Chronic Fatigue and Chemical Sensitivities in Gulf Registry Veterans.” Archives of Environmental Health 54, no. 5 (September-October 1999):309-11.
  • Kruetzer, R., Neutra, R., Lashuay, N. “Prevalence of People Reporting Sensitivities to Chemicals in a Population-Based Survey.” American Journal of Epidemiology 150, no. 1 (1999):1-12.
  • Lax, M., Henneberger, P. ‘Patients with Multiple Chemical Sensitivities in an Occupational Health Clinic: Presentation and Follow-up.” Archives of Environmental Health 50, no. 6 (1995):425-31.
  • Lee, T.G. “Health Symptoms Caused by Molds in a Courthouse.” Archives of Environmental Health 58, no. 7 (July 2003):442-46.
  • Levallois, P. Neutra, R., Lee, G., Hristoa, L. “Study of Self-Reported Hypersensitivity to Electromagnetic Fields in California.” Environmental Health Perspectives 110, Suppl. 4 (August 2002):619-23.
  • Lieberman, A.D., Craven, M.R. “Reactive Intestinal Dysfunction Syndrome (RIDS) Caused by Chemical Exposures.” Archives of Environmental Health 54, no. 5 (September-October 1999):365-66.
  • McFadden, S. “Phenotype Variation in Xenobiotic Metabolism and Adverse Environmental Response: Focus on Sulfur-Dependant Detoxification Pathways.” Toxicology 111 (1996):43-65.
  • McKeown-Eyssen, G., Baines, C., Cole, D.E., Riley, N., Tyndale, R.F., Marshall, L, Jazmaji, V. “Case-Control Study of Genotypes in Multiple Chemical Sensitivity: CYP2D6, NAT1, NAT2, PON1, PON2 and MTHFR.” International Journal of Epidemiology (July 15, 2004).
  • Meggs, W.J. “Hypothesis for Induction and Propagation of Chemical Sensitivity Based on Biopsy Studies.” Review. Environmental Health Perspectives 105 (March 1997).
  • Meggs, W.J. “Neurogenic Switching: A Hypothesis for a Mechanism for Shifting the Site of Inflammation in Allergy and Chemical Sensitivity.” Environmental Health Perspectives 103, no. 1 (January 1995):54-56.
  • Meggs, W.J. “RADS and RUDS-The Toxic Induction of Asthma and Rhinitis.” Clinical Toxicology 32, no. 5 (1994):487-501.
  • Meggs, W.J., Cleveland, C. “Rhinolaryngoscopic Examination of Patients with the Multiple Chemical Sensitivity Syndrome.” Archives of Environmental Health 41, no. 1 (1993):14-18.
  • Meggs, W.J., Dunn, K., Bloch, R., Goodman, P., Davidoff, L. “Prevalence and Nature of Allergy and Chemical Sensitivity in a General Population.” Archives of Environmental Health 51, no. 4 (1996):275-82.
  • Meggs, W.J., Elsheik, T., Metzger, W.J., Albernaz, M., Bloch, R.M. “Nasal Pathology and Ultrastructure in Patients with Chronic Airway Inflammation Following an Irritant Exposure.” Journal of Toxicology-Clinical Toxicology 34, no. 4 (1996):383-96.
  • Miller, C.S. “Possible Models for Multiple Chemical Sensitivity: Conceptual Issues and Role of the Limbic System. Advancing the Understanding of Multiple Chemical Sensitivity.” Toxicology and Industrial Health 8, no. 4 (1992):181-202.
  • Miller, C.S. “White Paper: Chemical Sensitivity: History and Phenomenology.” Toxicology and Industrial Health 10, no. 4-5 (1994):253-76.
  • Miller, C.S., Gammage R.B., Jankovic, J.T. “Exacerbation of Chemical Sensitivity: A Case Study.” Toxicology and Industrial Health 15, nos. 3-4 (April-June 1999):398-402.
  • Miller, C.S., Mitzel, H. “Chemical Sensitivity Attributed to Pesticide Exposure Versus Remodeling.” Archives of Environmental Health 50, no. 2 (1995):119.
  • Miller, C.S. “Toxicant-Induced Loss of Tolerance: An Emerging Theory of Disease?” Environmental Health Perspectives 105, Suppl. 2 (1997):445-53.
  • Miller, C.S., Prihoda, T. “The Environmental Exposure and Sensitivity Inventory (EESI): A Standardized Approach for Measuring Chemical Intolerances for Research and Applications.” Toxicology and Industrial Health 15 (1999):370-85.
  • Miller, C.S., Prihoda, T. “A Controlled Comparison of Symptoms and Chemical Intolerances Reported by Gulf War Veterans, Implant Recipients, and Persons with Multiple Chemical Sensitivity.” Toxicology and Industrial Health 15 (1999):386-97.
  • Miller, C.S., Ashford, N., Doty, R., Lamielle, M., Otto, D., Rahill, A., Wallace, L. “Empirical Approaches for the Investigation of Toxicant-Induced Loss of Tolerance.” Environmental Health Perspectives 105, Suppl. 2 (1997):515-19.
  • Miller, C.S., Gammage, R., Jankovic, J. “Exacerbation of Chemical Sensitivity: A Case Study.” Toxicology and Industrial Health 15 (1999):398-402.
  • Millqvist, E., Bengtsson, U., Lowhagen, O. “Provocations with Perfume in the Eyes Induce Airway Symptoms in Patients with Sensory Hyperreactivity.” Allergy 54, no. 5 (May 1999):495-99.
  • Millqvist, E., Ternesten-Hasséus, E., Ståhl, A., Bende, M. “Changes in Levels of Nerve Growth Factor in Nasal Secretions after Capsaicin Inhalation in Patients with Airway Symptoms from Scents and Chemicals.” Environmental Health Perspectives 113, no. 7 (July 2005):849-52.
  • Nethercott, J., Davidoff, L., Curbow, B., Abbey, H. “Multiple Chemical Sensitivities Syndrome: Toward a Working Case Definition.” Archives of Environmental Health 48 (1993):19-26.
  • Nogué, S., Fernández-Solá, J., Rovira, E., Montori, E., Fernández-Huerta, J.M., Munné, P. “Multiple Chemical Sensitivity: Study of 52 Cases.” Medicina Clinica (Barcelona) 129, no. 3 (June 16, 2007):96-98.
  • Nutter, T.J., Jiang, N., Cooper, B.Y. “Persistent Na+ and K+ Channel Dysfunctions After Chronic Exposure to Insecticides and Pyridostigmine Bromide.” Neurotoxicology 39 (December 2013):72-83.
  • Odegard, T.N., Cooper, C.M., Farris, E.A., Arduengo, J., Bartlett, J., Haley, R. “Memory Impairment Exhibited by Veterans with Gulf War Illness.” Neurocase 19, no. 4 (August 2013): 316-27.
  • Ojo, J.O., Abdullah, L., Evans, J., Reed, J.M., Montague, H., Mullan, M.J., Crawford, F.C. “Exposure to an Organophosphate Pesticide, Individually or in Combination with other Gulf War Agents, Impairs Synaptic Integrity and Neuronal Differentiation, and Is Accompanied by Subtle Microvascular Injury in a Mouse Model of Gulf War Agent Exposure.” Neuropathology (September 30, 2013).
  • Overstreet, D.H., Djuric, V. “A Genetic Rat Model of Cholinergic Hypersensitivity: Implications for Chemical Intolerance, Chronic Fatigue, and Asthma.” Annals of the New York Academy of Science 933 (March 2001):92-102.
  • Overstreet, D., Miller, C., Janowsky, D., Russell, R. “Potential Animal Model of Multiple Chemical Sensitivity with Cholinergic Supersensitivity.” Toxicology 111 (1996):119-34.
  • Pall, M.L. “Elevated Nitric Oxide-Peroxynitrite Theory of Multiple Chemical Sensitivity: Central Role of N-Methyl-D-Aspartate Receptors in the Sensitivity Mechanism.” Environmental Health Perspectives 111, no. 12 (September 2003):1461-1464.
  • Pall M.L., Anderson J.H. “The Vanilloid Receptor as a Putative Target of Diverse Chemicals in Multiple Chemical Sensitivity.” Archives of Environmental Health 59, no. 7 (2004):363-75.
  • Pigatto, P.D., Minoia, C., Ronchi, A., Brambilla, L., Ferrucci, S.M., Spadari, F., Passoni, M., Somalvico, F., Bombeccari, G.P., Guzzi, G. “Allergological and Toxicological Aspects in a Multiple Chemical Sensitivity Cohort.” Oxidative Medicine and Cellular Longevity (2013): 356235.
  • Piroli, A., Ciccozzi, A., Petrucci, E., Paladini, A., Marsili, I., Panella, L., Santucci, C., Coaccioli, S., Marinangeli, F. “Anaesthesia Management in Patients with Multiple Chemical Sensitivity Syndrome.” International Journal of Immunopathology and Pharmacology 26, no. 4 (October-December 2013):961-64.
  • Randolph, T.G. “Clinical Manifestations of Individual Susceptibility to Insecticides and Related Materials.” Industrial Medicine and Surgery 34 (February 1965):134-42.
  • Randolph, T.G. “Dynamics, Diagnosis, and Treatment of Food Allergy.” Review. Otolaryngology Clinics of North America 7, no. 3 (October 1974):617-35.
  • Randolph, T.G. “Ecologic Orientation in Medicine: Comprehensive Environmental Control in Diagnosis and Therapy.” Annals of Allergy 23 (January 1965):7-22.
  • Randolph, T.G. “Human Ecology and Susceptibility to the Chemical Environment.” Annals of Allergy 19 (May 1961):518-40.
  • Randolph, T.G. “Human Ecology and Susceptibility to the Chemical Environment: Air Pollution.” Annals of Allergy 19 (June 1961):657-77.
  • Randolph, T.G. “Human Ecology and Susceptibility to the Chemical Environment.” Annals of Allergy 19 (July 1961):779-99.
  • Randolph, T.G. “Human Ecology and Susceptibility to the Chemical Environment.” Annals of Allergy 19 (August 1961):908-29.
  • Rayhan, R.U., Raksit, M.P., Timbol, C.R., Adewuyi, O., Vanmeter, J.W., Baraniuk, J.N. “Prefrontal Lactate Predicts Exercise-Induced Cognitive Dysfunction in Gulf War Illness.” American Journal Translational Research 5, no. 2 (2013):212-23.
  • Rayhan, R.U., Ravindran, M.K., Baraniuk, J.N. “Migraine in Gulf War Illness and Chronic Fatigue Syndrome: Prevalence, Potential Mechanisms, and Evaluation.” Frontiers of Physiology 4 (July 24, 2013):181.
  • Rayhan, R.U., Stevens, B.W., Raksit, M.P., Ripple, J.A., Timbol, C.R., Adewuyi, O., VanMeter, J.W., Baraniuk, J.N. “Exercise Challenge in Gulf War Illness Reveals Two Subgroups with Altered Brain Structure and Function.” PLoS One 8, no. 6. (June 14, 2013):e63903.
  • Rayhan, R.U., Stevens, B.W., Timbol, C.R., Adewuyi, O., Walitt, B, VanMeter, J.W.,Baraniuk, J.N. “Increased Brain White Matter Axial Diffusivity Associated with Fatigue, Pain and Hyperalgesia in Gulf War Illness” PLoS One 8, no. 3 (2013):e58493.
  • Rea, W.J., Didriksen, N., Simon, T.R., Pan, Y., Fenyves, E.J., Griffiths, B. “Effects of Toxic Exposure to Molds and Mycotoxins in Building-Related Illnesses.” Archives of Environmental Health 58, no. 7 (July 2003):399-405.
  • Rea, W.J. “Environmentally Triggered Cardiac Disease.” Annals of Allergy 40 (April 1978):243-51.
  • Rea, W.J. “Environmentally Triggered Small Vessel Vasculitis.” Annals of Allergy 38 (April 1977):245-51.
  • Rea, W.J. “Environmentally Triggered Thrombophlebitis.” Annals of Allergy 37, no. 2 (August 1976):101-109.
  • Rea, W.J., Peters, D.W., Smiley, R.E., Edgar, R., Greenberg, M., Fenyves, E. “Recurrent Environmentally Triggered Thrombophlebitis: A Five-Year Follow-up.” Annals of Allergy 47, no. 5, pt.1 (November 1981):338-44.
  • Rogers, W.R., Miller, C.S., Bunegin, L. “A Rat Model of Neurobehavioral Sensitization to Toluene.” Toxicology and Industrial Health 15, nos. 3-4 (April-June 1999):356-69.
  • Ross, G.H. “Clinical Characteristics of Chemical Sensitivity: An Illustrative Case History of Asthma and MCS.” Environmental Health Perspectives 105, Suppl. 2 (March 1997):437-41.
  • Ross, G.H. “History and Clinical Presentation of the Chemically Sensitive Patient.” Toxicology and Industrial Health 8, no. 4 (July-August 1992):21-28.
  • Ross, G.H., Rea, W.J., Johnson, A.R., Hickey, D.C., Simon, T.R. “Neurotoxicity in Single Photon Computed Tomography Brain Scans of Patients Reporting Chemical Sensitivities.” Toxicology and Industrial Health 15 (1999):415-20.
  • Rossi, J. “Sensitization Induced by Kindling and Kindling-Related Phenomena as a Model for Multiple Chemical Sensitivity.” Toxicology 111, nos. 1-3 (July 17, 1996):87-100.
  • Schnakenberg, Eckart, Fabig, Karl-Rainer, Stanulla, Martin, Strobl, Nils, Lustig, Michael, Fabig, Nathalie, Schloot, Werner. “A Cross-Sectional Study of Self-Reported Chemical-Related Sensitivity Is Associated with Gene Variants of Drug-Metabolizing Enzymes.” Oxidative Medicine and Cellular Longevity (2013):351457.
  • Shirakawa, S., Ishikawa, S., Miyata, M., Rea, W.J., Johnson, A.R. “A Pupillographical Study on the Presence of Organochlorine Pesticides in Autonomic Nerve Disturbance.” Nippon Ganka Gakkai Zasshi 94, no. 4 (April 1990):418-23.
  • Simon, T.R., Hicket, D.C., Fincher, C.E., Johnson, A.R., Ross, G.H., Rea, W.J. “Single Photon Computed Tomography of the Brain in Patients with Chemical Sensitivities.” Toxicology and Industrial Health 10, nos. 4-5 (1994):573-77.
  • Simon, T.R., Rea, W.J. “Use of Functional Brain Imaging in the Evaluation of Exposure to Mycotoxins and Toxins Encountered in Desert Storm/Desert Shield.” Archives of Environmental Health 58, no. 7 (July 2003):406-409.
  • Sorg, B.A., Hochstatter, T. “Behavioral Sensitization After Repeated Formaldehyde Exposure in Rats.” Toxicology and Industrial Health 15, nos. 3-4 (April-June 1999):346-55.
  • Sorg, B.A. “Multiple Chemical Sensitivity: Potential Role for Neuralsensitization.” Review. Critical Reviews in Neurobiology 13, no. 3 (1999):283-316.
  • Sorg, B. “Proposed Animal Model for Multiple Chemical Sensitivity in Studies with Formalin.” Toxicology 111 (1996):135-45.
  • Spencer, T.R., Schur, P.M. “The Challenge of Multiple Chemical Sensitivity.” Journal of Environmental Health 70, no. 10 (June 2008):24-27.
  • Steinemann, A.C. “Fragranced Consumer Products and Undisclosed Ingredients.” Environmental Impact Assessment Review 29, no. 1 (2009):32-38.
  • Steinemann, A.C., Gallagher, L.G., Davis, A.L., MacGregor, I.C.. “Chemical Emissions from Residential Dryer Vents During Use of Fragranced Laundry Products.” Air Quality, Atmosphere and Health (2011).
  • Steinemann, A.C., MacGregor, I.C., Gordon, S.M., Gallagher, L.G., Davis, A.L., Ribeiro, D.S., Wallace, L.A.. “Fragranced Consumer Products: Chemicals Emitted, Ingredients Unlisted.” Environmental Impact Assessment Review 31, no. 3 (2011):328–33.
    Stephens, R., Spurgeon, A., Calvert, I., et al. “Neuropsychological Effect of Long-Term Exposure to Organophosphates in Sheep Dip.” Lancet 3459 (1995):1135-1139.
  • Ternesten-Hasseus, E., Bende, M., Millqvist, E. “Increased Capsaicin Cough Sensitivity in Patients with Multiple Chemical Sensitivity.” Journal of Occupational and Environmental Medicine 44, no. 11 (November 2002).
  • Ternesten-Hasseus, E., Larsson C., Larsson, S., Millqvist, E. “Capsaicin Sensitivity in Patients with Chronic Cough: Results from a Cross-Sectional Study.” Cough 9 (2013):5.
    Tillman, G.D., Calley, C.S., Green, T.A., Buhl, V.I., Biggs, M.M., Spence, J.S., Briggs,
  • R.W., Haley, R.W., Kraut, M.A., Hart, J. Jr. “Visual Event-Related Potentials as Markers of Hyperarousal in Gulf War Illness: Evidence Against a Stress-Related Etiology.” Psychiatry Research 211, no.3 (March 30, 2013):257-67.
  • Thrasher, J.D., Heuser, G., Broughton, A. “Immunological Abnormalities in Humans Chronically Exposed to Chlorpyrifos.” Archives of Environmental Health 57, no. 3 (May-June 2002):181-187.
  • Thrasher, J.D., Vojdani, A., Cheung, G., Heuser, G. “Evidence for Formaldehyde Antibodies and Altered Cellular Immunity in Subjects Exposed to Formaldehyde in Mobile Homes.” Archives of Environmental Health 42, no. 6 (November-December 1987):347-50.
  • Welch, L.S., Sokas, R. “Development of Multiple Chemical Sensitivity After an Outbreak of Sick-Building Syndrome.” Toxicology and Industrial Health 8, no. 4 (1991):47-65.
  • Wiesmuller, G.A., et al. “Nasal Function in Self-Reported Chemically Intolerant Individuals.” Archives of Environmental Health 57, no. 3 (May-June 2002):247-54.
  • Yun, M.J., Kang, D.M., Lee, K.H., Kim, Y.K., Kim, J.E. “Multiple Chemical Sensitivity Caused by Exposure to Ignition Coal Fumes: A Case Report.” Annals of Occupational & Environmental Medicine 25, no. 1 (November 1, 2013):32.
  • Ziem, G.E. “Multiple Chemical Sensitivity: Treatment and Follow-up with Avoidance and Control of Chemical Exposures. Advancing the Understanding of Multiple Chemical Sensitivity.” Toxicology and Industrial Health 8, no. 4 (1992):181-202.
  • Ziem, G.E., McTamney, J. “Profile of Patients with Chemical Injury and Sensitivity.” Environmental Health Perspectives 105, Suppl. 2 (March 1997):417-36.

Mast Cell Activation Syndrome (often the cause of MCS)

The Mast Cell Disease Society https://tmsforacure.org/research/

https://en.m.wikipedia.org/wiki/Mast_cell_activation_syndrome

http://www.mastcellaware.com/mast-cells/about-mast-cells.html

Lawrence B. Afrin et al., Often seen, rarely recognized: mast cell activation disease – a guide to diagnosis and therapeutic options, Annals of Medicine Volume 48, 2016 – Issue 3

Afrin, Lawrence B. “A Concise, Practical Guide to Diagnostic Assessment for Mast Cell Activation Disease.” WJH World Journal of Hematology 3.1 (2014): 155-232.

Brain mast cells link the immune system to anxiety-like behavior by Katherine M. Nautiyal, Ana C. Ribeiro, Donald W. Pfaffand Rae Silver

 Theoharides TC, Stewart JM, Hatziagelaki E, et al. Brain “fog,” inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin. Front Neurosci 2015;9:225. [PMC free article]

Anastasia I Petra,Smaro Panagiotidou,Julia M Stewart,Pio Conti &Theoharis C Theoharides Spectrum of mast cell activation disorders, Pages 729-739 | Published online: 01 May 2014, Expert Review of Clinical Immunology Volume 10, 2014 – Issue 6

Talkington J, Nickell SP. Borrelia burgdorferi Spirochetes Induce Mast Cell  Activation and Cytokine Release. McGhee JR, ed. Infection and Immunity. 1999;67(3):1107-1115.

Echtenacher B, Manne D N, Hultner L. Critical protective role of mast cells in a model of acute bacterial peritonitis. Nature. 1996;381:75–77.

Wilhelm M, Silver R, Silverman AJ. Central nervous system neurons acquire mast cell products via transgranulation. Eur J Neurosci 2005;22:2238-48. [PMC free article]

Akin C, Valent P, Metcalfe DD. Mast Cell Activation Syndrome: Proposed Diagnostic Criteria: Towards a global classification for mast cell disorders. The Journal of allergy and clinical immunology. 2010;126(6):1099-104.e4. doi:10.1016/j.jaci.2010.08.035.

Arck PC, Slominski A, Theoharides TC, et al.Neuroimmunology of stress: skin takes center stage. J Invest Dermatol 2006;126:1697-704. [PMC free article

Theoharides TC, Alysandratos KD, Angelidou A, et al. Mast cells and inflammation. Biochim Biophys Acta 2012;1822:21-33. [PMC free article]

Theoharides, Theoharis C., and Julia M. Stewart. “Genitourinary Mast Cells and Survival.” Translational Andrology and Urology 4.5 (2015): 579–586. PMC. Web. 23 Apr. 2018.

Theoharides TC. The mast cell: a neuroimmunoendocrine master player. Int J Tissue React 1996;18:1-21.

Wong GW, Zhuo L, Kimata K, et al. Ancient origin of mast cells. Biochem Biophys Res Commun 2014;451:314-8. [PMC free article]

Serafin WE, Austen KF. Mediators of immediate hypersensitivity reactions. N Engl J Med. 1987;317:30–34.

Dystych J, Walczak-Drzewiecka A, Wyczolkowska J, Metcalfe DD. Murine mast cells exposed to mercuric chloride release granule-associated N-acetyl-β -d-hexosaminidase and secrete IL-4 and TNF-α J Allergy Clin Immunol. 1999;103:1108–1114.

Esposito P, Gheorghe D, Kandere K, Pang X, Conally R, Jacobson S, Theoharides TC. Acute stress increases permeability of the blood-brain-barrier through activation of brain mast cells. Brain Res. 2001;888:117–127.
De Vreis HE, Kuiper J, de Boer AG, Va

Narita S, Goldblum RM, Watson CS, et al.Environmental estrogens induce mast cell degranulation and enhance IgE-mediated release of allergic mediators.Environ Health Perspect 2007;115:48-52. [PMC free article]

Kempuraj D, Papadopoulou N, Stanford EJ, et al.Increased numbers of activated mast cells in endometriosis lesions positive for corticotropin-releasing hormone and urocortin. Am J Reprod Immunol 2004;52:267-75.

Harvima IT, Nilsson G, Suttle MM, Naukkarinen A. Is there a role for mast cells in psoriasis? Arch.Dermatol Res. 2008;300:461–476. [

Woidacki K, Jensen F, Zenclussen AC. Mast cells as novel mediators of reproductive processes. Front Immunol2013;4:29. [PMC free article]

Theoharides TC, Cochrane DE. Critical role of mast cells in inflammatory diseases and the effect of acute stress. J Neuroimmunol 2004;146:1-12.

Maldonado MD, Mora-Santos M, Naji L, et al. Evidence of melatonin synthesis and release by mast cells. Possible modulatory role on inflammation. Pharmacol Res2010;62:282-7

Theoharides TC, Petra AI, Stewart JM, et al. High serum corticotropin-releasing hormone (CRH) and bone marrow mast cell CRH receptor expression in a mastocytosis patient.J Allergy Clin Immunol 2014;134:1197-9

Rottem M, Mekori YA. Mast cells and autoimmunity.Autoimmun Rev 2005;4:21-7.

Pedotti R, De Voss JJ, Steinman L, Galli SJ. Involvement of both ‘allergic’ and ‘autoimmune’ mechanisms in EAE, MS and other autoimmune diseases. Trends Immunol. 2003;24:479–484.

Goines PE, Ashwood P. Cytokine dysregulation in autism spectrum disorders (ASD): possible role of the environment. Neurotoxicol Teratol. 2013;36:67–81.[PMC free article]

Li X, Chauhan A, Sheikh AM, Patil S, Chauhan V, Li XM, Ji L, Brown T, Malik M. Elevated immune response in the brain of autistic patients. J Neuroimmunol. 2009;207(1–2):111–116. [PMC free article]

Mostafa GA, Hamza RT, El-Shahawi HH. Allergic manifestations in autistic children: Relation to disease severity. Journal of Pediatric Neurology. 2008;6(2):115–123.

Pardo CA, Vargas DL, Zimmerman AW. Immunity, neuroglia and neuroinflammation in autism. Int Rev Psychiatry. 2005;17(6):485–495.

Wouters MM, Vicario M, Santos J The role of mast cells in functional GI disorders. Gut. 2016 Jan;65(1):155-68. doi: 10.1136/gutjnl-2015-309151. Epub 2015 Jul 20.

Aravindakshan J, Gregory M, Marcogliese DJ, Fournier M, Cyr DG. Consumption of xenoestrogen-contaminated fish during lactation alters adult male reproductive function. Toxicol Sci. 2004;81:179–189.

Steinman L (2004) Elaborate interactions between the immune and nervous systems. Nat Immunol 5:575–581.

Silver R, Silverman AJ, Vitkovic L, Lederhendler II   (1996) Mast cells in the brain: Evidence and functional significance. Trends Neurosci19:25–31.

 

Silverman AJ, Sutherland AK, Wilhelm M, Silver R(

2000) Mast cells migrate from blood to brain. J Neurosci20:401–408

Lehrer PM, Isenberg S, Hochron SM

 (1993) Asthma and emotion: A review. J Asthma 30:5–21

Addolorato G, et al.

 (1998) Anxiety and depression: A common feature of health care seeking patients with irritable bowel syndrome and food allergy. Hepatogastroenterology 45:1559–1564.

Maier SF

 (2003) Bi-directional immune-brain communication: Implications for understanding stress, pain, and cognition. Brain Behav Immun 17:69–85.

 

 

Books

Tired or Toxic? By Sherry A Rogers MD

Why Can’t I Get Better? By Dr Horowitz (Although about Lyme disease, it has the only in depth, scientific, medical information I’ve found about why MCS happens, the right way to do tests and treatment. Just for understanding the liver detoxification pathways it’s worth owning.)

Explaining ‘Unexplained Illnesses’: Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, and Gulf War Syndrome by Martin L. Pall

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